Principal Software Engineer

endpointclinical· 530 G&A - Product Engineering (Product Engineering)
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🌍 Remote📍 Remote USF Full Time💰 USD 160K–170K

About this role

About Us:

Endpoint is an interactive response technology (IRT®) systems and solutions provider that supports the life sciences industry. Since 2009, we have been working with a single vision in mind, to help sponsors and pharmaceutical companies achieve clinical trial success. Our solutions, realized through the proprietary PULSE® platform, have proven to maximize the supply chain, minimize operational costs, and ensure timely and accurate patient dosing. Endpoint is headquartered in Raleigh-Durham, North Carolina with offices across the United States, Europe, and Asia.

Weʼre seeking a principal software engineer who is passionate, experienced and skilled, versatile, and customer-and business- oriented. In this role, we will also need someone who is full-stack and polyglot (see specific technologies below). This is a critical technical leadership role. As a principal engineer you will define the technical direction of our forecasting product, allowing us to scale and mentoring other engineers. You will also operate as a primary technical authority across multidisciplinary teams, partnering tightly with customers, partners and especially internal stakeholders, translating fundamental needs into technological solutions that drive the business.

Responsibilities

  • Partner closely with product and executive leadership to inform and implement company strategy. Work with internal stakeholders such as Product and UX to rapidly distill initially ambiguous requirements into concrete and actionable plans
  • Be a strong, hands-on contributor delivering code and features day-to-day
  • Drive technical strategy and architecture for our product across all engineering domains
  • Champion operational excellence: reliability, quality, and continuous risk reduction across the product. Document and oversee implementation of the engineering standards that ensure it.
  • Own the security and compliance posture appropriate our product, e.g. SOC 2,data integrity, and potentially GxP/21 CFR Part 11 consideration
  • Accelerate application development and uplevel engineering staff via mentorship and selecting relevant trainings, conferences, and events for the team
  • Help grow the team: interviewing, hiring, and raising the technical bar as we scale
  • Represent engineering with customers and other internal and external stakeholders
  • Be AI-literate, leveraging the latest technologies to inform the technical and
  • Product roadmap. You will educate internal stakeholders on how the latest technologies work and contribute key ideas to conversations about how they can be leveraged in the product

Experience

  • 12+ years of engineering excellence
  • A proven track record of architecting, scaling, and maintaining complex, scaled systems
  • Past responsibilities involve systems with large numbers of users in environments where quality, security, and reliability are critical
  • Polyglot mastery and a proven ability to learn new languages and architectures.
  • Ability to hit the ground running — someone who is already proficient in our current stack

Education

  • Bachelors degree or higher in Computer Science or other relevant field preferred

Skills Required

      • Should be expertise in front end technologies: TypeScript, React
      • Should have good experience in NodeJS
      • Rust ideally (ideally), or Go/C++
      • Amazon Web Services and Azure (ideally), or equivalent
      • CI/CD: GitHub Actions, or equivallent
      • Infrastructure-as-code solutions like Terraform, Pulumi or equivalent
Endpoint Clinical does not accept unsolicited resumes from search firms or any other third parties. Any unsolicited resume sent to Endpoint Clinical will be considered Endpoint Clinical property, and Endpoint Clinical will not pay a fee should it hire the subject of any unsolicited resume.

Endpoint Clinical is an equal opportunities employer AA/M/F/Veteran/Disability.    
 
Pursuant to the San Francisco Fair Chance Ordinance, we will consider for employment, qualified applicants with arrest and conviction records.
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Frequently Asked Questions

What is the salary for the Principal Software Engineer role at endpointclinical?
The listed salary for this Principal Software Engineer position at endpointclinical is USD 160K–170K. This is a remote F Full Time role.
Is the Principal Software Engineer job at endpointclinical remote?
Yes, this Principal Software Engineer position at endpointclinical is remote, with team members based in Remote US. You can work from home or anywhere in the supported regions.
Is the Principal Software Engineer role at endpointclinical full-time or part-time?
This is listed as a F Full Time position. It is posted as a Principal Software Engineer role in the 530 G&A - Product Engineering (Product Engineering) department at endpointclinical.
Which team or department does the Principal Software Engineer at endpointclinical belong to?
This Principal Software Engineer position is part of the 530 G&A - Product Engineering (Product Engineering) department at endpointclinical. See the full job description for more information about the team structure and responsibilities.
How do I apply for the Principal Software Engineer position at endpointclinical?
Click the "Apply Now" button on this page. You will be redirected to endpointclinical's official application portal hosted on lever where you can submit your application directly.
When was the Principal Software Engineer job at endpointclinical posted?
This Principal Software Engineer position at endpointclinical was posted on Aug 14, 2026. Apply as soon as possible — early applications are often reviewed first.
Principal Software Engineer
endpointclinical · 💰 USD 160K–170K
Apply for this role ↗

You'll be redirected to endpointclinical's official application page on Lever.