Senior Scientist Ⅱ, DSP( Preparative Purification )

Location.

The actual location of this job is Guangzhou in China.

What you will get

• An agile career and dynamic working culture.
• An inclusive and ethical workplace.
• Compensation programs that recognize high performance.
• A variety of benefits dependent on role and location.
• The full list of our global benefits can be found here: https://www.lonza.com/careers/benefits.

What you will do:

Key Technical Requirements: Preparative Purification Expert (Small Molecules & ADC Drug-Linkers)

• We are seeking an experienced purification scientist with deep expertise in preparative chromatography, isolation sciences, and scalable purification process development for complex small molecules, drug-linkers, and related intermediates.

Core Technical Competencies

Preparative Chromatography

• Extensive experience in preparative HPLC method development and scale-up.
• Strong expertise in reverse-phase and normal-phase chromatography.
• Experience with column screening, loading optimization, gradient development, recovery improvement, and productivity enhancement.

Complex Molecule Purification

• Proven experience purifying highly functionalized small molecules, ADC drug-linkers, payloads, and complex intermediates.
• Ability to develop purification strategies for compounds with challenging impurity profiles.
• Experience separating closely related impurities, regioisomers, diastereomers, and residual starting materials or by-products.

Process Development & Scale-Up

• Demonstrated experience transferring purification processes from laboratory scale to pilot and GMP manufacturing scale.
• Understanding of process robustness, manufacturability, productivity, solvent consumption, and cost considerations.
• Ability to design purification strategies suitable for multi-gram to kilogram-scale production.

Preferred Experience

• ADC drug-linker development and manufacturing.
• Cytotoxic payload or highly potent compound purification.
• GMP manufacturing support and technology transfer.
• Collaboration with Process Chemistry, Analytical Development, and Manufacturing teams.
• Experience serving as a Subject Matter Expert (SME) in purification and isolation sciences.

Ideal Candidate Profile

• An experienced purification SME who can design and implement scalable purification strategies for complex small molecules and ADC drug-linkers, balancing purity, yield, productivity, cost, and manufacturability, while supporting projects from early development through GMP manufacturing.

Qualification:

• A Master’s degree with at least 7 years of industry experience, or a PhD with at least 2 years of industry experience, in Chemistry, Pharmaceutical Sciences, Chemical Engineering, or a related discipline.
• Strong expertise in preparative HPLC development, process optimization, troubleshooting, and scale-up, including both reverse-phase and normal-phase chromatography.
• A successful track record of designing and implementing scalable purification solutions for complex small molecules, with a focus on quality, efficiency, and manufacturability.
• Excellent English communication skills, enabling collaboration in a global environment and effective authoring of technical documentation.

It would be a plus if you have:

• Experience with ADC linkers, payloads, highly potent compounds, or other challenging small molecule modalities.
• Experience in downstream process development and scale-up in a pharmaceutical manufacturing environment.
• Exposure to GMP manufacturing, technology transfer, or kilogram-scale process development.
• Experience serving as a technical expert and collaborating across Process Chemistry, Analytical Development, and Manufacturing functions.

About Lonza

At Lonza, our people are our greatest strength. With 30+ sites across five continents, our globally connected teams work together every day to manufacture the medicines of tomorrow. Our core values of Collaboration, Accountability, Excellence, Passion and Integrity reflect who we are and how we work together. Everyone’s ideas, big or small, have the potential to improve millions of lives, and that’s the kind of work we want you to be part of.

Innovation thrives when people from all backgrounds bring their unique perspectives to the table. At Lonza, we value diversity and are committed to creating an inclusive environment for all employees. If you’re ready to help turn our customers’ breakthrough ideas into viable therapies, we look forward to welcoming you on board.

Ready to shape the future of life sciences? Apply now.