Regional Business Director, East

Company Description

Deciphera, a member of Ono Pharmaceutical Co., Ltd., is a biopharmaceutical company focused on discovering, developing, and commercializing important new medicines and providing hope to people living with cancer, neurologic and autoimmune disease. Deciphera is leveraging its proprietary switch-control kinase inhibitor platform and deep expertise in kinase biology to develop a broad portfolio of innovative medicines. In addition to advancing multiple product candidates from Deciphera’s platform in clinical studies, QINLOCK® (ripretinib) is Deciphera’s switch-control kinase inhibitor approved in many countries including the European Union and the United States for the treatment of adult patients with advanced gastrointestinal stromal tumor (GIST) who have received prior treatment with 3 or more kinase inhibitors, including imatinib. ROMVIMZA® (vimseltinib) is a kinase inhibitor approved in the United States for adult patients with symptomatic tenosynovial giant cell tumor (TGCT) for which surgical resection will potentially cause worsening functional limitation or severe morbidity, and in the European Union for adult patients with TGCT associated with clinically relevant physical function deterioration and in whom surgical options have been exhausted or would induce unacceptable morbidity or disability.   

The spirit of collaboration that has brought medications to life continues to guide how we operate, grow, and discover new breakthroughs. We cultivate an inclusive culture that values curiosity, creativity, and shared accountability—empowering individuals to challenge the unknown together. 

Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care. 

Job Description

The Regional Business Director will prepare for the anticipated launch of tirabrutinib, a highly potent and selective Bruton tyrosine kinase (BTK) inhibitor being advanced for patients with relapsed or refractory primary central nervous system lymphoma (R/R PCNSL). PCNSL is a rare and aggressive extra-nodal non-Hodgkin lymphoma with significant unmet need, and tirabrutinib represents an important potential new treatment option for patients facing limited therapeutic choices. 

The Regional Business Director will lead a regional sales team and play a critical role in shaping launch readiness by building regional business plans, developing team capabilities, and partnering closely with Market Access, Medical Affairs, Marketing, Commercial Operations, and other cross-functional stakeholders to prepare for a successful launch and support Deciphera’s efforts to bring tirabrutinib to patients in need. 

Key Responsibilities

Commercial Strategy & Business Planning (25%) 

• Develop and execute regional business plans aligned with organizational strategy, including clear actions, timelines, and success metrics  

• Analyze market dynamics, customer segments, and business performance to inform strategy and decision-making. Identify customer needs and align organizational resources to effectively meet those needs  

• Provide strategic input to commercial planning, including feedback on tools, resources, and field execution strategies   

• Develop data-driven assessments of business performance and provide recommendations to optimize future outcomes 

Sales Leadership & Execution Excellence (30%) 

• Lead team execution to achieve or exceed business objectives through effective prioritization, planning, and resource utilization  

• Ensure effective use of tools (e.g., CRM systems) to manage customer engagement, track progress, and optimize performance  

• Partner with cross-functional stakeholders to deliver a seamless and compliant customer experience  

• Optimize territory alignment, customer targeting, and field activities to maximize impact  

• Ensure completion of required administrative and compliance-related activities 

Talent Leadership & Team Development (25%) 

• Lead and develop a high-performing sales team through coaching, feedback, and performance management  

• Establish clear performance expectations aligned with business goals and organizational values  

• Assess individual and team capabilities, identify gaps, and implement targeted development plans  

• Foster a culture of continuous learning, improvement, and accountability  

• Attract, develop, and retain top talent while building a strong leadership pipeline 

 Cross-Functional Leadership & Enterprise Collaboration (10%) 

• Partner effectively with internal stakeholders (e.g., Market Access, Marketing, Medical, Commercial Operations, Training) to drive aligned execution 

• Influence and contribute to broader commercial strategy and organizational initiatives  

• Share insights and best practices across teams to enhance overall business performance  

• Build strong, collaborative relationships across field and home office functions 

Culture, Compliance & Operational Leadership (10%) 

• Promote a culture grounded in integrity, accountability, collaboration, and patient focus  

• Ensure all activities are conducted in compliance with company policies, industry standards, and regulatory requirements  

• Manage regional budgets and operational activities in alignment with business objectives  

• Lead with a strong ethical framework and reinforce expected behaviors across the team 

Other duties and responsibilities as assigned  

Qualifications

Required Qualifications 

• Bachelor’s degree in business, life sciences, or related discipline 

• 12+ years of experience in the pharmaceutical or biotechnology industry including 3+ years front-line malignant hematology sales experience and 5+ years experience in malignant hematology or oncology sales leadership roles  

• Demonstrated experience recruiting, organizing, developing, and retaining a cohesive, high performing sales team 

• Proven track record of delivering results in competitive, complex environments  

• Strong ability to analyze data, generate insights, and inform business strategy  

• Experience collaborating across cross-functional partners to achieve business objectives  

• Strong communication, leadership presence, and interpersonal skills 

Preferred Capabilities 

• Advanced degree (e.g., MBA, MPH, PharmD, PhD) 

• Oncology or specialty pharmaceutical experience  

• Experience in rare disease and/or complex, access-driven markets  

• Experience supporting or building commercial capabilities (e.g., sales operations, analytics, training)  

• Strong understanding of the full commercial ecosystem (e.g., marketing, market access, insights & analytics)  

• Experience leading in dynamic, fast-paced, or growth-oriented environments  

• Demonstrated ability to influence without authority and operate across multiple levels of the organization 

Additional Information

Deciphera is committed to fair and equitable compensation practices. The base salary pay range for this role is $208,000 - $286,000. Actual compensation packages will depend on various factors, including, but not limited to depth of experience, education, skillset, overall performance and/or location.​

Deciphera believes in providing a competitive compensation and benefits package to all employees. Our base salary is just one component of Deciphera’s competitive total rewards strategy that also includes annual performance bonus, a long-term incentive plan, full range of benefits and other incentive compensation plans (if applicable)

Benefits:

• Competitive salary and annual bonus.
• Comprehensive benefits package including medical, dental, vision insurance, 401(k) retirement plan with company match, and more.
• Generous parental leave and family planning benefits.
• Outstanding culture and opportunities for personal and professional growth.

Apply Now: Join us in our mission to improve the lives of people with cancer. Apply today to become a part of our dynamic team!

EQUAL EMPLOYMENT OPPORTUNITY INFORMATION

Deciphera is committed to equal employment opportunity and values diversity. To ensure that we comply with reporting requirements, we invite you complete the confidential survey at the end of this application. Providing this information is optional. It will not be accessible or used in the hiring process, and has no effect on your opportunity for employment. This information will also be treated confidentially.  We are committed to make all hiring decisions and other employment decisions on a non-discriminatory basis.

EQUAL EMPLOYMENT OPPORTUNITY INFORMATION

Deciphera is committed to equal employment opportunity and values diversity. To ensure that we comply with reporting requirements, we invite you complete the confidential survey at the end of this application. Providing this information is optional. It will not be accessible or used in the hiring process, and has no effect on your opportunity for employment. This information will also be treated confidentially.  We are committed to make all hiring decisions and other employment decisions on a non-discriminatory basis.