Real World Evidence Associate Director

vrtx· Vertex Pharmaceuticals Inc (US)
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📍 Boston, MAFull time💰 USD 174K–262K

About this role

Job Description

General Summary:

The RWE Associate Director is an integral member of the RWE team who leverages expertise in epidemiology and real world data to develop fit-for-purpose observational research, and to inform internal and external stakeholders on natural history (NH) of disease and real world outcomes within their assigned therapeutic area. The RWE Associate Director works cross-functionally to support the execution of observational research across the portfolio.

Key Duties and Responsibilities:

  • Independently lead focused/targeted research of epidemiology of specific disease areas, including NH of disease for business development and early development indications
  • Lead data sourcing strategy for early development and early clinical indications to support NH of disease needed for regulators, payers, and clinicians
  • Lead and execute evaluation of available registries and other data sources related to NH and evidence to support clinical endpoints and inclusion/exclusion criteria
  • Determine potential use of RWE historical control within clinical development program and feasibility of obtaining data required for historical control
  • Lead execution of approved research tactics within assigned indications
  • Develop draft protocol concept and related materials for review and approval by internal scientific review boards
  • Working closely with stakeholders, align RWE research study tactics with functional and disease program goals
  • Contribute to development of performance metrics and dashboards for RWE projects
  • Represent RWE on relevant GMDA Sub-Teams, Program Teams, or Disease Strategy Teams where studies related to RWE are discussed
  • Represent RWE on cross-functional collaborations and working groups for pipeline product(s)
  • Utilize strong oral communications skills and understanding of Vertex strategies to promote and translate RWD/RWE methods and activities across the company
  • Support and facilitate external research collaborations with key academic partners, consortia, and data vendors
  • Support the development of cross-functional evidence generation planning
  • Provide leadership and mentorship within RWE
  • Contribute to company publications strategy via development of conference abstracts, presentations, peer-reviewed manuscripts based on the findings of RWE studies

    • Knowledge and Skills:

  • Applied knowledge of relevant RWE regulatory agency guidance and position papers and the opportunities to use RWE to inform regulatory decision making
  • Demonstrated ability to design and execute observational research
  • Strong and clear interpersonal communication, presentation, and study management skills
  • Ability to take detailed observational study results and communicate them in a clear, non- technical manner to internal cross-functional teams, using language that resonates with the teams, while maintaining the integrity of key findings
  • Ability to work collaboratively in a constantly changing, diverse, and matrix environment

    • Education and Experience:

  • PhD (preferred), or MS/MPH in epidemiology, biostatistics, health economics and outcomes research, or similar required
  • Formal graduate training in Epidemiology/Health Services Research required
  • Minimum 5 years of experience working in observational research within the life sciences industry or relevant academic, government, or consulting environment
  • Minimum 3 years of experience working in RWE and/or Epidemiology at a biopharmaceutical company


    • At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

    Pay Range:

    $174,400 - $261,600

    Disclosure Statement:

    The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

    At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations.  From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

    Flex Designation:

    Hybrid-Eligible Or On-Site Eligible

    Flex Eligibility Status:

    In this Hybrid-Eligible role, you can choose to be designated as: 
    1.    Hybrid: work remotely up to two days per week; or select
    2.    On-Site: work five days per week on-site with ad hoc flexibility.

    Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. 

    #LI-Hybrid
     

    Company Information

    Vertex is a global biotechnology company that invests in scientific innovation.

    Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

    Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

    Frequently Asked Questions

    What is the salary for the Real World Evidence Associate Director role at vrtx?
    The listed salary for this Real World Evidence Associate Director position at vrtx is USD 174K–262K. This is an Full time role.
    Where is the Real World Evidence Associate Director position at vrtx located?
    This Real World Evidence Associate Director role at vrtx is based in Boston, MA. The position is listed as on-site or hybrid. Check the full job description or apply directly to confirm the work arrangement.
    Is the Real World Evidence Associate Director role at vrtx full-time or part-time?
    This is listed as a Full time position. It is posted as a Real World Evidence Associate Director role in the Vertex Pharmaceuticals Inc (US) department at vrtx.
    Which team or department does the Real World Evidence Associate Director at vrtx belong to?
    This Real World Evidence Associate Director position is part of the Vertex Pharmaceuticals Inc (US) department at vrtx. See the full job description for more information about the team structure and responsibilities.
    How do I apply for the Real World Evidence Associate Director position at vrtx?
    Click the "Apply Now" button on this page. You will be redirected to vrtx's official application portal hosted on workday where you can submit your application directly.
    When was the Real World Evidence Associate Director job at vrtx posted?
    This Real World Evidence Associate Director position at vrtx was posted on Sep 14, 2026. Apply as soon as possible — early applications are often reviewed first.
    Real World Evidence Associate Director
    vrtx · 💰 USD 174K–262K
    Apply for this role ↗

    You'll be redirected to vrtx's official application page on Workday.