US: Sr. Cell Therapy Clinical Educator (Gulf Coast)
legendcareers
Principal Scientist, Clinical Biomarker, Immunology & Immuno-Oncology (Hematology)
legendcareers· Global Translational Research
About this role
Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life-threatening diseases. Headquartered in Bridgewater, New Jersey, we are advancing the next generation of cell therapy through a portfolio of innovative technologies, including autologous, allogeneic, and in vivo cell therapy approaches. Our research spans chimeric antigen receptor T-cell (CAR-T), T-cell receptor (TCR-T), natural killer (NK) cell-based therapies, and other emerging platforms designed to transform the treatment of serious diseases. From our global network of research and development sites, we are committed to discovering and developing safe, effective, and cutting-edge therapies for patients worldwide.
Legend Biotech entered into a global collaboration agreement with Johnson & Johnson to jointly develop and commercialize CARVYKTI® (ciltacabtagene autoleucel; cilta-cel). Through this strategic partnership, we combine complementary expertise and capabilities to advance innovative immunotherapies for patients living with multiple myeloma.
Legend Biotech is seeking a Principal Scientist, Clinical Biomarker, Immunology & Immuno-Oncology (Hematology) as part of the Early Drug Development team based in Somerset, NJ.
Role Overview
We are seeking a highly motivated and innovative Principal Scientist to join our immunology and immuno-oncology (IO) clinical biomarker projects, with a dedicated focus on hematological malignancies. In this role, you will drive the clinical translational understanding of novel therapy in hematology. You will serve as the biology lead on cross-functional project teams, drive MOA of novel cell therapy and clinical biomarker strategy.
Key Responsibilities
- Scientific Leadership: Design, execute, and analysis results from clinical studies to investigate the mechanisms of action for novel IO targets in hematological indications (e.g., AML, DLBCL, Multiple Myeloma).
- Translational Strategy: Bridge discovery and clinical development by utilizing primary human samples and clinical datasets to validate targets and understand the immune microenvironment in hematology.
- Understanding MOA: Oversee the generation and interpretation of high-dimensional molecular and cellular data. Leverage advanced single-cell technologies (e.g., scRNA-seq) to deeply profile immune cell compartments, particularly T-cell states and exhaustion markers, to inform patient stratification and biomarker hypotheses.
- Cross-Functional Collaboration: Partner closely with other functional teams for better understanding of MOA and fundamental immunology.
Requirements
- Ph.D. in Immunology, Immuno-Oncology, Cellular Biology, or a closely related discipline, can initiate and lead data driven MOA studies. Experience with cell therapy a plus but not required.
- A minimum of 5-8+ years of post-doctoral and/or industry experience in biotech or pharma, with a proven track record of advancing IO programs. Deep understanding of immunology, particularly T cell biology highly desirable.
- Hematology Expertise: Deep biological understanding of hematological malignancies and the unique tumor immune microenvironment of the blood and bone marrow.
- Experience working with multiple dimensional data, extract biological insights from data highly desirable.
- Exceptional written and verbal communication skills, with the ability to distill complex data into clear, actionable strategic decisions.
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The base pay range below is what Legend Biotech USA Inc. reasonably expects to offer at the time of posting. Actual compensation may vary based on experience, skills, qualifications, and geographic location. The company reserves the right to modify this range as needed and in accordance with applicable laws.
Other Types of Pay: Performance-based bonus and/or equity is available to employees in eligible roles.
Benefits and Paid Time Off: Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays. Additional voluntary benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide voluntary commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs; demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.
Pay Range (Base Pay):
$146,410—$192,164 USD
Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.
Work Authorization & Employment Eligibility
Applicants must be authorized to work in the United States. As part of our commitment to maintaining a lawful workforce and ensuring compliance with federal employment regulations, we participate in the E-Verify program. If you are selected for employment, you will be required to complete the Form I-9 process, and your employment eligibility will be verified through E-Verify in accordance with applicable federal law. We are committed to providing a fair, transparent, and welcoming hiring experience for all candidates.
EEO Statement
It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.
Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.
For information related to our privacy notice, please review: Legend Biotech Privacy Notice.
Frequently Asked Questions
What is the salary for the Principal Scientist, Clinical Biomarker, Immunology & Immuno-Oncology (Hematology) role at legendcareers?
The listed salary for this Principal Scientist, Clinical Biomarker, Immunology & Immuno-Oncology (Hematology) position at legendcareers is USD 146K–192K. This is an full-time role.
Where is the Principal Scientist, Clinical Biomarker, Immunology & Immuno-Oncology (Hematology) position at legendcareers located?
This Principal Scientist, Clinical Biomarker, Immunology & Immuno-Oncology (Hematology) role at legendcareers is based in Somerset, New Jersey, United States. The position is listed as on-site or hybrid. Check the full job description or apply directly to confirm the work arrangement.
Which team or department does the Principal Scientist, Clinical Biomarker, Immunology & Immuno-Oncology (Hematology) at legendcareers belong to?
This Principal Scientist, Clinical Biomarker, Immunology & Immuno-Oncology (Hematology) position is part of the Global Translational Research department at legendcareers. See the full job description for more information about the team structure and responsibilities.
How do I apply for the Principal Scientist, Clinical Biomarker, Immunology & Immuno-Oncology (Hematology) position at legendcareers?
Click the "Apply Now" button on this page. You will be redirected to legendcareers's official application portal hosted on greenhouse where you can submit your application directly.
When was the Principal Scientist, Clinical Biomarker, Immunology & Immuno-Oncology (Hematology) job at legendcareers posted?
This Principal Scientist, Clinical Biomarker, Immunology & Immuno-Oncology (Hematology) position at legendcareers was posted on Jun 16, 2026. Apply as soon as possible — early applications are often reviewed first.
Principal Scientist, Clinical Biomarker, Immunology & Immuno-Oncology (Hematology)
legendcareers · 💰 USD 146K–192K
You'll be redirected to legendcareers's official application page on Greenhouse.