MES Technical Lead / Systems Architect LP2

lilly· 712 Lly Lebanon Adv Therapies
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📍 US, Lebanon INFull time💰 USD 129K–211K

About this role

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us. 


LP2 MES Technical Lead & Systems Architect — Lebanon, Indiana 

Lilly is building a new gene therapy manufacturing site (LP2) in Lebanon, Indiana. This role owns the Manufacturing Execution System (MES) end-to-end — from the Tulip application layer and Tulip Table data model, through MuleSoft integrations connecting SAP, QbDVision, and LabVantage, to the MQTT-based Unified Namespace driving real-time equipment communication. You will serve as both the technical authority over the platform’s architecture and the hands-on engineer responsible for its ongoing design, build, and validation. 

 

Key Responsibilities 

  • Serve as Technical Lead/SME for LP2 MES architecture, design standards, and technical direction 

  • Design, build, and validate Tulip applications for GxP manufacturing workflows and electronic batch records 

  • Direct automation integrations with Automation Engineering (equipment commands, confirmations, process value subscriptions) 

  • Author/approve design specs ensuring compliance with ALCOA+ and 21 CFR Part 11 

  • Guide components through validated migration lifecycle (DEV → QA → Production) 

  • Participate in Change Control Board (CCB) and ServiceNow change management 

  • Partner with Manufacturing Operations, Automation Engineering, and Quality (BQA/CSQA) 

  • Mentor MES engineers; act as escalation point for complex issues 

  • Collaborate with MES Product Owner on ALM requirements/backlog 

  • Report system status and technical risk to site/IT leadership 

 

Basic Requirements 

  • Bachelor's degree in IT, Software/Computer Engineering or related field 

  • 5+ years with MES or pharma manufacturing IT platforms, including system integration (middleware/ERP/PLM) and Computer System Validation (CSV) in GMP settings 

  • Qualified applicants must be authorized to work in the United States on a full-time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F-1 CPT, F-1 OPT, F-1 STEM OPT, J-1, H-1B, TN, O-1, E-3, H-1B1, or L-1. 

 

Additional Skills/Preferences 

  • Modern software architecture and integration patterns 

  • MuleSoft/Anypoint, DataWeave for MES–ERP(SAP)–PLM integrations 

  • MQTT, Unified Namespace (UNS), OPC UA knowledge 

  • CSV experience: Validation/Test Plans, IQ/OQ/UAT, design specs under 21 CFR Part 11/ALCOA+ 

  • Understanding of eBRs, non-terminal record controls, e-signatures 

  • Git/GitHub, GitHub Actions, MUnit, ALM/Jira 

  • Familiarity with MABL and ServiceNow 

  • Strong cross-functional communication and problem-solving skills 

 

Additional Information: 

  • Position Location: Lebanon, Indiana, with potential travel to other U.S. and global Lilly sites as required. 

  • Travel Percentage (%): <10 

  • Shift Information: Role is Monday through Friday and based on-site. Must be flexible in providing support to accommodate production schedules, batch execution windows, and change control activities. Occasional extended hours and/or off-hour support may be required. 

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.


Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.


Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).


Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

$129,000 - $211,200

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

#WeAreLilly

Frequently Asked Questions

What is the salary for the MES Technical Lead / Systems Architect LP2 role at lilly?
The listed salary for this MES Technical Lead / Systems Architect LP2 position at lilly is USD 129K–211K. This is an Full time role.
Where is the MES Technical Lead / Systems Architect LP2 position at lilly located?
This MES Technical Lead / Systems Architect LP2 role at lilly is based in US, Lebanon IN. The position is listed as on-site or hybrid. Check the full job description or apply directly to confirm the work arrangement.
Is the MES Technical Lead / Systems Architect LP2 role at lilly full-time or part-time?
This is listed as a Full time position. It is posted as a MES Technical Lead / Systems Architect LP2 role in the 712 Lly Lebanon Adv Therapies department at lilly.
Which team or department does the MES Technical Lead / Systems Architect LP2 at lilly belong to?
This MES Technical Lead / Systems Architect LP2 position is part of the 712 Lly Lebanon Adv Therapies department at lilly. See the full job description for more information about the team structure and responsibilities.
How do I apply for the MES Technical Lead / Systems Architect LP2 position at lilly?
Click the "Apply Now" button on this page. You will be redirected to lilly's official application portal hosted on workday where you can submit your application directly.
When was the MES Technical Lead / Systems Architect LP2 job at lilly posted?
This MES Technical Lead / Systems Architect LP2 position at lilly was posted on Sep 11, 2026. Apply as soon as possible — early applications are often reviewed first.
MES Technical Lead / Systems Architect LP2
lilly · 💰 USD 129K–211K
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You'll be redirected to lilly's official application page on Workday.