Director of Protein Biochemistry

Director of Protein Biochemistry

PacBio (NASDAQ: PACB) is a premier life science technology company that designs, develops, and manufactures advanced sequencing solutions to help scientists and clinical researchers resolve genetically complex problems. Our mission is to enable the promise of genomics to better human health. Genomics is core to all biological processes, and our advanced genomics tools provide scientists and clinical researchers the insights to better understand biology and health. We are now entering the century of biology and genomics is at the heart of the next revolution. Become part of the new paradigm in gene sequencing and help shape the future of genomic study by joining the PacBio team.

Position Summary

PacBio is seeking a Director of Protein Biochemistry to lead protein engineering and single-molecule biochemistry efforts supporting the development and advancement of its long-read, single-molecule sequencing platforms. This individual will direct a five-person multidisciplinary team with expertise in protein biochemistry, protein engineering, single-molecule microscopy, biophysics, enzymology, and computational and statistical analysis.

The Director will provide scientific leadership and people management, integrating experimental and analytical approaches to advance proteins and biochemical systems for sequencing applications.

Responsibilities

• Direct protein engineering and single-molecule biochemistry research to develop and optimize proteins and biochemical systems for PacBio’s long-read, single-molecule sequencing platforms.
• Lead, mentor, and develop a five-person team spanning experimental, engineering, and computational disciplines.
• Establish scientific priorities, research plans, and milestones aligned with sequencing platform development goals.
• Guide protein biochemical characterization, single-molecule biophysical measurements, and enzymology studies to understand performance and inform engineering strategies.
• Integrate microscopy, biochemical measurements, and computational and statistical analyses to guide experimental design and research decisions.
• Collaborate with cross-functional partners to translate research findings into improvements in sequencing platform performance.
• Communicate research progress, technical challenges, and recommendations to scientific collaborators and leadership.

Required Qualifications

• PhD in biochemistry, biophysics, molecular biology, bioengineering, or a closely related discipline.
• At least 15 years of relevant industry experience.
• At least 10 years of management experience leading scientific or technical teams.
• Strong knowledge of protein and nucleic acid chemistry, structural biology, single-molecule biophysical analysis, genomic analysis, and next-generation sequencing technologies.
• Experience directing protein engineering and biochemical research programs.
• Ability to guide multidisciplinary teams and integrate experimental findings with quantitative analysis.
• Excellent interpersonal, written, and verbal communication skills.

Preferred Experience

• Experience applying AI and/or machine learning methods as applied to protein engineering, biochemical research, or sequencing data analysis.
• Bioinformatics expertise relevant to genomic analysis and sequencing technologies.

Candidates must have current authorization to work in the United States without the need for present or future sponsorship.

Non-Field Based Employees are required to be onsite Monday-Thursday (Friday work from home). Depending on the role, some employees may be required to be 100% onsite.

You may be required from time to time to visit and work at PacBio locations and for such times as the Company considers necessary for the proper performance of your duties.

All listed tasks and responsibilities are deemed as essential functions to this position; however, business conditions may require reasonable accommodations for additional tasks and responsibilities.

All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.

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All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, protected veteran status, or on the basis of disability, gender identity, and sexual orientation.

If you are an individual with a disability and require a reasonable accommodation to complete any part of the application process, or are limited in the ability or unable to access or use this online application process and need an alternative method for applying, you may contact us at 650-521-8000, or careers@pacificbiosciences.com for assistance.

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