Director, Drug Substance

revolutionmedicines· Drug Substance
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📍 Redwood City, California, United States💰 USD 211K–264K

About this role

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

Playing a critical role as a technical lead within the Drug Substance function, the position will be responsible for process research and development and scale-up of manufacturing in support of Revolution Medicines’ pipeline compound development, clinical programs and commercial readiness.   

Responsibilities:

  • Responsible for developing chemical processes for the manufacture of drug substance, intermediates and/or starting materials, including route evaluation and process optimization.

  • Conduct process development and optimization studies according to the principles of quality by design (QbD), to enable regulatory starting materials designation, establish control strategy and process characterization studies using tools such as design of experiment (DOE) studies.

  • Lead and/or enable technology transfer, process familiarization, and manufacturing at CDMOs.

  • Participate in identification, selection, and management of CROs and CDMOs including management of redundant supply and geographic diversity.

  • Write, review, and approve protocols, manufacturing batch records, and development and campaign reports.

  • Author, review the relevant CMC sections of regulatory filings and patent applications.

  • Partner with analytical development, pharmaceutical development, and supply chain functions to design overall strategy for programs.

  • Communicate effectively within cross functional project teams.

  • Travel to CRO/CDMO for the oversight of development activities and manufacturing (up to approximately 15%).

Required Skills, Experience and Education:

  • PhD (minimum MSc degree) in organic chemistry, chemical engineering or related discipline.

  • 10 or more years (15+ years for Master’s degree) of relevant industrial experience in chemical / drug substance process research and development.

  • Strong people management skills.

  • Hands-on proficiency in synthetic organic chemistry.

  • Knowledge of current ICH guidelines, GMP, and relevant industry practices.

  • Working experience and knowledge of regulatory submissions (IND, IMPD, NDA and MAA).

  • Previous experience managing projects at CROs/CDMOs.

  • Strong problem solving skills with sound technically driven decision-making ability.

  • Effective written and verbal communication skills and interpersonal skills.

  • An innovative team-player with high energy for our dynamic company environment. #LI-Hybrid #LI-CT1

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact privacy@revmed.com.

Base Pay Salary Range
$211,000—$264,000 USD

We are aware of recent recruitment scams in which individuals or organizations falsely represent themselves as being affiliated with Revolution Medicines. These scams may appear as false job advertisements or unsolicited contacts through communication or chat platforms, email, phone, or text message.
 
Please note that Revolution Medicines does not extend unsolicited employment offers and will never ask candidates to provide financial information, purchase equipment, or pay fees as part of the hiring process. All legitimate communication from Revolution Medicines will come from an official @revmed.com email address.
 
If you believe you’ve been contacted by someone impersonating a Revolution Medicines recruiter, please report it to careers@revmed.com so we can share these impersonations with our IT team for tracking and awareness.

 

Frequently Asked Questions

What is the salary for the Director, Drug Substance role at revolutionmedicines?
The listed salary for this Director, Drug Substance position at revolutionmedicines is USD 211K–264K. This is an full-time role.
Where is the Director, Drug Substance position at revolutionmedicines located?
This Director, Drug Substance role at revolutionmedicines is based in Redwood City, California, United States. The position is listed as on-site or hybrid. Check the full job description or apply directly to confirm the work arrangement.
Which team or department does the Director, Drug Substance at revolutionmedicines belong to?
This Director, Drug Substance position is part of the Drug Substance department at revolutionmedicines. See the full job description for more information about the team structure and responsibilities.
How do I apply for the Director, Drug Substance position at revolutionmedicines?
Click the "Apply Now" button on this page. You will be redirected to revolutionmedicines's official application portal hosted on greenhouse where you can submit your application directly.
When was the Director, Drug Substance job at revolutionmedicines posted?
This Director, Drug Substance position at revolutionmedicines was posted on Jun 12, 2026. Apply as soon as possible — early applications are often reviewed first.
Director, Drug Substance
revolutionmedicines · 💰 USD 211K–264K
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